Images like this confocal reflectance micrograph of healthy articular cartilage are used to track matrix deformation and determine how loading impacts matrix structure. We hypothesize that osteoarthritic tissue will exhibit a reduced sensitivity to dynamic load-induced improvements in properties and an enhanced sensitivity to degradative changes associated with stress deprivation and static loading. In order to analyse the joint contact mechanics in real, anatomical joints, the cartilage model needs to be implemented into a suitable finite element code. Meanwhile, changes in microscopic mechanical and structural parameters are monitored optically and cell biosynthetic activity is assessed. The results highlight a deeper connection between the cartilage friction and the lubrication film formation, which allows for better understanding of the cartilage lubrication mechanism. Compressive, shear and tensile loading regimens with varying frequencies and stress amplitudes are imposed on both healthy cartilage and cartilage with experimental osteoarthritis. of contact using established methods24, 25, implemented in PostView. The issue of lubrication in natural joints is not. We are investigating this question using a unique device allowing for evaluation of tissue-, matrix- and cellular-level mechanical properties in live tissue explants over extended periods of time. Labrum load support, and labrum and acetabular cartilage contact stress and contact. The right function of synovial joints ensures well lubricated contact surfaces with very low friction coefficient and wear of cartilage tissue. At each time step of a simulation, ray casting was used in conjunction with hierarchical oriented bounding boxes (OBB) to rapidly identify regions. Knee mechanics were then predicted within the context of a dynamic gait simulation. Hi all, I am using an elastic foundation model to compute cartilage contact surface pressures for the knee in a multibody simulation of gait in our custom. However, it is not known how the sensitivity of cartilage to ameliorative and detrimental loading regimens is impacted by this disease. We created a knee model that included articular cartilage contact for the tibiofemoral and patellofemoral joints. Osteoarthritis is characterized by reduced matrix synthesis and increased matrix degradation, resulting in pain and loss of mobility. These load-induced changes are mediated in part by cellular deformations induced by tissue-level strains. While dynamic loading typically promotes biosynthetic activity and improves mechanical properties, immobilization and static loads inhibit anabolic activity and are detrimental to tissue function. The metabolic activity of articular cartilage and other connective tissues is regulated by mechanical loading. Real-time Visualization of the Effects of Cyclic and Static Loading on Healthy and Pathological Cartilage Mechanical and Structural Properties UR Entrepreneurship & Translational Research real-time-visualization Real-time Visualization of the Effects of Cyclic and Static Loading on Healthy and Pathological Cartilage Mechanical and Structural Properties.
0 Comments
Leave a Reply. |